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KMID : 1161420230260040224
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Journal of Medicinal Food
2023 Volume.26 No. 4 p.224 ~ p.231
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Protective Effects of Cudrania tricuspidata Against Helicobacter pylori-Induced Inflammation in C57BL/6 Mice
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Lee Jeong-Yoon
Son Hyung-Gu
Koo Ye-Jin
Jung Seung-Hee
Park Soo-Dong
Jeong Byeong-Ho
Lee Jung-Lyoul
Lee Yoo-Hyun
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Abstract
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Helicobacter pylori modulates the host inflammatory response, resulting in chronic gastritis, which contributes to gastric cancer pathogenesis. We verified the effect of Cudrania tricuspidata on H. pylori infection by inhibiting H. pylori-induced inflammatory activity. Five-week-old C57BL/6 mice (n?=?8) were administered C. tricuspidata leaf extract (10 or 20?mg/kg per day) for 6 weeks. An invasive test (campylobacter-like organism [CLO]) and noninvasive tests (stool antigen test [SAT] and H. pylori antibody enzyme-linked immunosorbent assay) were performed to confirm the eradication of H. pylori. To evaluate the anti-inflammatory effect of C. tricuspidata, pro-inflammatory cytokines levels and inflammation scores were measured in mouse gastric tissue. C. tricuspidata significantly decreased the CLO score and H. pylori immunoglobulin G antibody optical density levels at both 10 and 20?mg/kg per day doses (P?
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KEYWORD
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C57BL/6, Cudrania tricuspidata, gastric inflammation, Helicobacter pylori, pro-inflammatory cytokines
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